Marshall Edwards
 
   
About Phenoxodiol

Frequently asked questions

Clinical Trials

 
1. Where does Phenoxodiol come from?
2. What is Phenoxodiol and how is it made?
3. What effect does Phenoxodiol have on cancer cells?
4. How does Phenoxodiol work?
5. What side-effects does Phenoxodiol have?
6. How is Phenoxodiol given?
7. What cancers may Phenoxodiol be useful for?
8. Where is Phenoxodiol in its development?


1. Where does Phenoxodiol come from?

Phenoxodiol was designed to target a key protein that is crucial to the survival and growth of many types of human cancer. That protein is known as sphingosine kinase. Inhibiting this protein robs the cancer cell of its ability to multiply and to remain immortal.

TOP

2. What is Phenoxodiol and how is it made?

Phenoxodiol is a small molecule belonging to the chemical family known as isoflavenes.

It is a synthetic chemical produced by standard synthetic chemistry.

TOP

3. What effect does Phenoxodiol have on cancer cells?

Phenoxodiol

  • stops cancer cells from dividing (cytostatic)
  • reduces the migration of cancer cells (anti-metastatic)
  • inhibits the formation of new blood vessels to the cancer (anti-angiogenic)
  • induces cancer cells to die by the natural process of apoptosis (cytotoxic).

TOP

4. How does Phenoxodiol work?

Studies are underway to understand the full range of actions of Phenoxodiol.

In simplest terms, Phenoxodiol regulates the most primitive balancing mechanism in the cell that governs whether the cell will survive or whether it will die. In order for cancer cells to survive and multiply, they need to override this balancing mechanism, preventing the cell from self-destructing. Phenoxodiol restores this balance mechanism, allowing the cell to self-destruct.

The fact that Phenoxodiol is working at this most basic level of control means that it is able to kill cancer cells irrespective of what has caused the cancer or what or how many malfunctions there are in the cancer cell.

Click here to find out more details about the mode of action of Phenoxodiol.

TOP

5. What side-effects does Phenoxodiol have?

Phenoxodiol only inhibits growth and survival mechanisms in cancer cells. The same mechanisms in healthy, non-cancer cells are unaffected. Phenoxodiol has not been associated in human use with any side-effects of note.

TOP

6. How is Phenoxodiol given?

Phenoxodiol can be given orally, intravenously, or through the skin. Currently both the oral and intravenous dosage forms are under development.

TOP

7. What cancers may Phenoxodiol be useful for?

In the test-tube, Phenoxodiol is effective against almost all types of human cancer. This includes breast, prostate, lung, ovarian and colorectal carcinomas, melanoma, mesothelioma, leukemias, rhabdomyosarcoma and neuroglioma.

The current clinical trial program is focused on ovarian, renal and prostate carcinoma and leukemias.

TOP

8. Where is Phenoxodiol in its development?

Phenoxodiol currently is undergoing Phase I and Phase II clinical studies. Those studies are being conducted at hospitals in both Australia and the US.

TOP

about Phenoxodiol
.

 

home : about us. : about phenoxodiol : the technology : newsroom :
: how to invest : contact details : credits : email

Marshall Edwards Inc. 2001 ©